RNF128 Antibody, Biotin conjugated
Catalogue Number: CSB-PA837448LD01HU-CSB
| Manufacturer: | Cusabio Biotech |
| Preservative: | 0.03% ProClin™ 300 |
| Ph: | 7.4 |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Conjugated |
| Alias: | E3 ubiquitin protein ligase RNF128 antibody; E3 ubiquitin-protein ligase RNF128 antibody; FLJ23516 antibody; Gene related to anergy in lymphocytes protein antibody; GRAIL antibody; RING finger protein 128 antibody; RN128_HUMAN antibody; RNF128 antibody |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug, 50 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Recombinant Human E3 ubiquitin-protein ligase RNF128 protein (229-400AA) |
| Application: | ELISA |
Description
Description: E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals.
Additional Text
Gene Name
RNF128
Uniprot ID
Q8TEB7
Purification
Protein G purified
Gene ID
79589
Storage Note
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Antibody Clonality
Polyclonal
CSB-PA837448LD01HU Datasheet
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