Recombinant Rabbit Interleukin-2 (IL2)

Catalogue Number: CSB-YP011629RBC7-CSB

Manufacturer:	Cusabio Biotech
Shelf Life:	6 months
Molecular Weight:	16.6 kDa
Physical state:	Liquid or Lyophilized powder
Type:	Interleukins
Alias:	IL-2;T-cell growth factor;TCGF
Host Cell:	Yeast
Shipping Condition:	Blue Ice
Unit(s):	1 mg, 100 ug, 20 ug
Host name:
Clone:
Isotype:
Immunogen:

Overview
Datasheets

Description

Description: Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.

Additional Text

Gene Name

IL2

UniProt ID

O77620

Gene ID

100302458

Protein Tag

6xHIS Tag

Storage Note

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

CSB-YP011629RBC7 MSDS

Price

£1,897.00

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