Recombinant Human Tumor necrosis factor(TNF),partial (Active)
Catalogue Number: CSB-YP023955HU-CSB
| Manufacturer: | Cusabio Biotech |
| Shelf Life: | 6 months |
| Molecular Weight: | 19.4 kDa |
| Physical state: | Lyophilized |
| Type: | Cytokines |
| Alias: | Cachectin TNF-alpha Tumor necrosis factor ligand superfamily member 2 |
| Host Cell: | Yeast |
| Shipping Condition: | Blue Ice |
| Unit(s): | 500 ug, 100 ug, 20 ug |
Description
Description: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918).
Additional Text
Uniprot ID
P01375
Protein Tag
6xHIS Tag
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