Recombinant Human Novel Coronavirus Spike glycoprotein(S), partial (Active)

Catalogue Number: CSB-YP3324GMY1-CSB

Manufacturer:Cusabio Biotech
Type:Other Recombinant Protein
Host Cell:Yeast
Shipping Condition:Blue Ice
Unit(s): 1 mg, 100 ug


Description: ‚ÄčA cDNA ORF corresponding to the 319-541 AA of human SARS-CoV-2 spike glycoprotein (S) was expressed with an N-terminal 6xHis-sumostar-tag in the yeast. The product is the partial-length recombinant human novel coronavirus (SARS-CoV-2) S protein. Its purity is greater than 90% determined by SDS-PAGE. The gel showed a band with a molecular weight of approximately 68 kDa, which was confirmed to be due to glycosylation after EndoH digestion. More importantly, its biological activity was validated by the functional ELISA and LSPR Assay. And it may be used in the research area of microbiology. This recombinant SARS-CoV-2 S protein is in-stock now.

SARS-CoV-2 S protein is composed of S1 subunit and S2 subunit. During viral infection, the receptor-binding domain (RBD) of the S1 subunit is responsible for the recognition and binding of host receptor ACE2, while the S2 subunit mediates viral cell membrane fusion. The SARS-CoV-2-S1-RBD/ACE2 interaction mediates viral entry into the target cells. The cleavage by TMPRSS2 primes the S protein for cell entry.


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