Recombinant Mouse Na (+)/H (+) exchange regulatory cofactor NHE-RF3 (Pdzk1)
Catalogue Number: CSB-YP862368MO-CSB
| Manufacturer: | Cusabio Biotech |
| Shelf Life: | 6 months |
| Molecular Weight: | 57.3 kDa |
| Physical state: | Liquid or Lyophilized powder |
| Type: | Other Recombinant Protein |
| Alias: | NHERF-3;CFTR-associated protein of 70 kDa;NaPi-Cap1;PDZ domain-containing protein 1;Sodium-hydrogen exchanger regulatory factor 3 |
| Host Cell: | Yeast |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg, 100 ug, 20 ug |
| Host name: | |
| Clone: | |
| Isotype: | |
| Immunogen: |
Description
Description: A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function.
Additional Text
Gene Name
PDZK1
Gene ID
59020
UniProt ID
Q9JIL4
Protein Tag
6xHIS Tag
Storage Note
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
CSB-YP862368MO MSDS
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