Cynomolgus M-CSF R/CSF1R/CD115 Protein (CSF-CM11R)
Catalogue Number: CSF-CM11R-KAT
CSF-CM11R Image
CSF-CM11R Image
CSF-CM11R Image
CSF-CM11R Image
CSF-CM11R Image
The purity of Cynomolgus M-CSF R is greater than 95% as determined by SEC-HPLC.
CSF-CM11R Image
Cynomolgus M-CSF R on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
CSF-CM11R Image
Cynomolgus M-CSF R, His Tag immobilized on CM5 Chip can bind Cynomolgus M-CSF, His Tag with an affinity constant of 0.889 uM as determined in SPR assay (Biacore T200).
CSF-CM11R Image
Immobilized Cynomolgus M-CSF R, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Anti-M-CSF R Antibody, hFc Tag with the EC50 of 5.6ng/ml determined by ELISA (QC Test).
| Manufacturer: | Kactus |
| Shelf Life: | 12 months |
| Molecular Weight: | The protein has a predicted MW of 56.3 kDa. Due to glycosylation, the protein migrates to 75-105 kDa based on Bis-Tris PAGE result. |
| Physical state: | Lyophilized |
| Type: | Protein Kinases |
| Alias: | CD115; CSF1R; CSF-1-R; CSFR; FMSFIM2; M-CSF R; MCSFR; M-CSFR; C-FMS; FIM2; FMS; HDLS |
| Host Cell: | HEK293 cells |
| Shipping Condition: | RT |
| Unit(s): | 100 ug, 500 ug |
| Application: | ELISA, WB |
Description
Description: CSF1R also known as M-CSF receptor, the product of the c-fms proto-oncogene, is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-like domains in their extracellular domain (ECD) and a split kinase domain in their intracellular region.CSF1R is tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes.
Additional Text
Protein Tag
HIS Tag
Uniprot ID
G7P8P1
Short Description
Recombinant Cynomolgus M-CSF R/CSF1R/CD115 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ile99-Pro596.
Storage Note
-20 to -80°C for 12 months as supplied from date of receipt.; -80°C for 3 months after reconstitution.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Biological Activity
Immobilized Cynomolgus M-CSF R, His Tag at 1Oeg/ml (100Oel/well) on the plate. Dose response curve for Anti-M-CSF R Antibody, hFc Tag with the EC50 of 14.4ng/ml determined by ELISA. The affinity constant of 0.889 OeM as determined in SPR assay (Biacore T200). See testing image for detail.
Endotoxin
Less than 1 EU per µg by the LAL method.
CSF-CM11R Datasheet
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