Human M-CSF R/CSF1R/CD115 Protein (CSF-HM21R)
Catalogue Number: CSF-HM21R-KAT
CSF-HM21R Image
CSF-HM21R Image
CSF-HM21R Image
CSF-HM21R Image
CSF-HM21R Image
Human M-CSF, His Tag captured on CM5 Chip via Anti-his Antibody can bind Human M-CSF R, hFc Tag with an affinity constant of 0.24 nM as determined in SPR assay (Biacore T200).
CSF-HM21R Image
The purity of Human M-CSF R is greater than 95% as determined by SEC-HPLC.
CSF-HM21R Image
Human M-CSF R on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
CSF-HM21R Image
Immobilized Human M-CSF, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Human M-CSF R, hFc Tag with the EC50 of 26.3ng/ml determined by ELISA (QC Test).
| Manufacturer: | Kactus |
| Shelf Life: | 12 months |
| Molecular Weight: | The protein has a predicted MW of 81.3 kDa. Due to glycosylation, the protein migrates to 100-130 kDa based on Bis-Tris PAGE result. |
| Physical state: | Lyophilized |
| Type: | Protein Kinases |
| Alias: | CD115; CSF1R; CSF-1-R; CSFR; FMSFIM2; M-CSF R; MCSFR; M-CSFR; C-FMS; FIM2; FMS; HDLS |
| Host Cell: | HEK293 cells |
| Shipping Condition: | RT |
| Unit(s): | 100 ug, 500 ug |
| Application: | ELISA, WB |
Description
Description: CSF1R also known as M-CSF receptor, the product of the c-fms proto-oncogene, is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-like domains in their extracellular domain (ECD) and a split kinase domain in their intracellular region.CSF1R is tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes.
Additional Text
Protein Tag
hFC Tag
Short Description
Recombinant Human M-CSF R/CSF1R/CD115 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Ile20-Glu512.
UniProt ID
P07333-1
Storage Note
-20 to -80°C for 12 months as supplied from date of receipt.; -80°C for 3 months after reconstitution.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Biological Activity
Immobilized Human M-CSF, His Tag at 0.5Oeg/ml (100Oel/well) on the plate. Dose response curve for Human M-CSF R, hFc Tag with the EC50 of 14.2ng/ml determined by ELISA. The affinity constant of 0.24 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Endotoxin
Less than 1 EU per µg by the LAL method.
CSF-HM21R Datasheet
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