MLN4924 (Pevonedistat)
Catalogue Number: CV-1006-1-RPE
| Manufacturer: | rPeptide |
| Physical state: | Lyophilized |
| Type: | Enzyme Inhibitors |
| Shipping Condition: | RT |
| Unit(s): | 1 mg |
Description
Description: Potent and selective NEDD8-activating enzyme (NAE) inhibitor. It disrupts cullin-RING ligase-mediated protein turnover leading to apoptosis in human tumor cells. Suppresses the growth of human tumor xenografts in mice. Upregulates PD-L1 expression and enhances the efficacy of immune checkpoint blockade in glioblastoma. Modulates tumor microenvironment. Cell permeable
SUPPORT
outstanding technical support
PRODUCT
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DELIVERY
we offer free delivery to UK universities and non profit organisations