Catalogue Number: CV-1033-1-RPE
Manufacturer: | rPeptide |
Physical state: | Pale yellow to off-white powder |
Type: | Kinase Inhibitors |
Shipping Condition: | RT |
Unit(s): | 5 mg |
Description: A necrostatin-1 analog with superior potency, selectivity and metabolic stability at RIP1 inhibition (IC50 = 206 vs 494 nM). Displays greater efficacy at inhibition of necroptosis in Jurkat cells with no non-specific cytotoxicity (100 nM). Ameliorates disease progression in elastase-induced mouse abdominal aortic aneurysm model. Recommended for cellular and in vivo applications over necrostatin-15.