BI 2536
Catalogue Number: CV-1035-2-RPE
| Manufacturer: | rPeptide |
| Physical state: | Lyophilized |
| Type: | Kinase Inhibitors |
| Shipping Condition: | RT |
| Unit(s): | 25 mg |
Description
Description: BI-2536 was originally reported as a potent (IC50's Plk1=0.83 nM, Plk2=3.5 nM and Plk3=9.0 nM) and selective Polo-like kinase inhibitor that caused mitotic arrest and apoptosis induction in various human cancer cell lines. It was later found to be a potent inhibitor (IC50=100 nM) of BET family member BRD4 and able to potently suppress c-Myc expression in MM.1S multiple myeloma cells. BI-2536 destabilizes N-Myc by inhibiting the deactivation of the ubiquitin E3 ligase Fbw7 by Plk1.
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