I-BET762
Catalogue Number: CV-1036-1-RPE
| Manufacturer: | rPeptide |
| Physical state: | Tan Powder |
| Type: | Other Inhibitors |
| Shipping Condition: | RT |
| Unit(s): | 5 mg |
Description
Description: I-BET762 is a potent inhibitor of the BET family of bromodomains with no activity at bromodomains BAZ2B, SP140, ATAD2, CREBBO, and PCAF. IC50's for H4Ac peptide displacement: BRD2=32.5 nM, BRD3=42.4nM, BRD4=36.1nM. It was able to suppress key inflammatory genes as well as the release of proinflammatory cytokines and prevent acute inflammation in mice. Suppresses the inflammatory function of T cells. Inhibition of BET bromodomains results in downregulation of Myc transcription, an important oncogene.
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