NE-100
Catalogue Number: CV-1037-1-RPE
| Manufacturer: | rPeptide |
| Physical state: | Lyophilized |
| Type: | Other Inhibitors |
| Shipping Condition: | RT |
| Unit(s): | 5 mg |
Description
Description: NE-100 is potent inhibitor of the sigma receptor (σ) with selectivity for sigma-1 (IC50=1.5 nM) over sigma-2 (IC50=85 nM). NE-100 suppressed ischemia-induced neuronal cell death in mice via upregulation of GRP78 through the ATF6 pathway resulting in suppression of ER stress-induced cell death in a sigma-1-independent manner.
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