S1RA (E-52862)
Catalogue Number: CV-1038-2-RPE
| Manufacturer: | rPeptide |
| Physical state: | Lyophilized |
| Type: | Other Inhibitors |
| Shipping Condition: | RT |
| Unit(s): | 25 mg |
Description
Description: S1RA (E-52862) is a potent and selective σ1 antagonist with weak binding at σ2 (IC50 σ1=17 nM, σ2=9300 nM) S1RA abolished mechanical and thermal hyperalgesia in mice with carrageenan-induced acute inflammation by enhancing the action of endogenous opioid peptides of immune origin in a σ1-dependent manner. S1RA potentiated µ-opioid antinociception in mice in a σ-dependent manner. Also displays neuroprotective effects in a mouse model of ischemic stroke.
SUPPORT
outstanding technical support
PRODUCT
we offer a full product guarantee
DELIVERY
we offer free delivery to UK universities and non profit organisations