RIPA-56
Catalogue Number: CV-1043-1-RPE
| Manufacturer: | rPeptide |
| Physical state: | Lyophilized |
| Type: | Kinase Inhibitors |
| Shipping Condition: | RT |
| Unit(s): | 10 mg |
Description
Description: RIPA-56 is a potent (IC50=13 nM, EC50=28 nM for HT-29 cells) and selective inhibitor of Receptor-Interacting Protein 1 (RIP1) kinase with significant metabolic stability (t1/2=128 min human liver microsomal stability assay). RIPA-56 showed excellent kinase selectivity and did not inhibit IDO at 200 µM. It was able to block the progression of multiple sclerosis in an immune-induced demyelination model.
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