Nitazoxanide
Catalogue Number: CV-1044-1-RPE
| Manufacturer: | rPeptide |
| Physical state: | Lyophilized |
| Type: | Enzyme Inhibitors |
| Shipping Condition: | RT |
| Unit(s): | 10 mg |
Description
Description: Nitazoxanide is a clinically useful antiparasitic agent. It has since been repurposed as a broad-spectrum antiviral agent that is active against many RNA and DNA viruses including influenza, hepatitis B and C, RSV, coronavirus, dengue and others. Its antiparasitic activity is believed to be due to inhibition of pyruvate:ferredoxin/flavodoxin oxidoreductases. Antiviral activity involves activation of protein kinase activated by double-stranded RNA (PKR) leading to phosphorylation of eukaryotic initiation factor 2 alpha (eIF2α). Nitazoxanide has also been found to inhibit Wnt signaling independent of adenomatous polyposis coli (APC), targeting peptidyl arginine deiminase 2 (PAD2) resulting in increased citrullination of β-catenin.
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