Volasertib
Catalogue Number: CV-1045-1-RPE
| Manufacturer: | rPeptide |
| Physical state: | Lyophilized |
| Type: | Kinase Inhibitors |
| Shipping Condition: | RT |
| Unit(s): | 5 mg |
Description
Description: Volasertib is an extremely potent and selective inhibitor of Polo-like kinase, a critical controller of multiple essential steps of mitosis (IC50: Plk1=0.87 nM, Plk2=5 nM, Plk3=56 nM). It has shown efficacy in multiple solid xenograft tumors models1 and in clinical studies in patients with acute myeloid leukemia. Volasertib has also been shown to potently inhibit BRD4 (Kd=79 nM3, IC50's bromodomains 1 and 2 of BRD4=300 and 770 nM respectively).
SUPPORT
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PRODUCT
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DELIVERY
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