Aprotinin
Catalogue Number: CV-3048-3-RPE
| Manufacturer: | rPeptide |
| Physical state: | Lyophilized |
| Type: | Protease Inhibitor Protein |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 g |
Description
Description: Aprotinin inhibits the activity of several proteolytic enzymes such as chymotrypsin, kallikrein, plasmin and trypsin. It is present in blood and in most tissues, with a high concentration in lung, inhibits pro-inflammatory cytokine release and maintains glycoprotein homeostasis. In platelets, aprotinin reduces glycoprotein loss (e.g., GpIb, GpIIb/IIIa), while in granulocytes it prevents the expression of pro-inflammatory adhesive glycoproteins. Aprotinin is a natural proteinase inhibitor polypeptide consisting of fifty-eight amino acids arranged in a single polypeptide chain, cross-linked by three disulfide bridges and having a molecular mass of 6512 Daltons. Aprotinin is purified by proprietary chromatographic techniques. It has been found to inhibit SARS-CoV and SARSCoV-2 in vitro.
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