Anti-CD73 (Hu) from Mouse (KK3)

Catalogue Number: DIA-KK3-DIA

Manufacturer:	Dianova
Preservative:	0.05% Sodium azide
Physical state:	Lyophilized
Type:	Monoclonal Primary Antibody - Unconjugated
Alias:	5-NT;5-Nucleotidase;Nt5e;5'-Nucleotidase;CD73;NT5-E;E5NT;E5-NT;EN;ENT;5'-Nucleotidase, Ecto
Shipping Condition:	RT
Storage Condition:	2-8°C
Unit(s):	500 ul
Host name:	Mouse
Clone:	KK3
Isotype:	IgG2a, kappa
Immunogen:	Recombinant peptide of human CD73
Application:	IHC

Overview
Datasheets

Description

Description: Clone KK3 has been developed and validated specifically for the immunohistochemical (IHC) detection of CD73 in routine FFPE human tissue specimen. Given the broad expression of ectonucleotidases and adenosine receptors, immunohisto-chemical (IHC) application of monoclonal antibody KK3 may help to develop a better understanding of cell- and tissue- specific roles. CD73 and CD39 are cell surface enzymes that catabolize the breakdown of extracellular ATP into adenosine. As ectonucleo-sidases they play important roles in maintaining tissue and immune homeostasis through interfering with the extracellular purigeneric pathway. Since several labs independently have demonstrated an immunosuppressive role of CD73-adenosine in cancer, the CD73-adenosine axis has emerged as one of the most promising therapeutic targets in immuno-oncology. Adenosine triphosphate (ATP) is the major source of energy for the cell. Malignant cells can release high levels of ATP (e.g. after damage by radiotherapy or chemotherapy). Extracellular ATP provokes inflammation by driving "purinergic signals&rsquo and plays a significant role in promoting anti-tumor responses. Many tumors express the ectonucleotidases CD39 and CD73 to scarve such proinflammatory mediators and generate immunosuppressive adenosine nucleosides.

Additional Text

Gene Name

NT5E

Gene ID

4907

Uniprot ID

P21589

Purification

Purified

Antibody Clonality

Monoclonal

DIA-KK3 Datasheet

Price

£488.00

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