Cleaved-NOTCH1 (V1754) Polyclonal Antibody
Catalogue Number: E-AB-30054-ELA
E-AB-30054 Image
E-AB-30054 Image
E-AB-30054 Image
E-AB-30054 Image
Western Blot analysis of Mouse brain, Rat musle using Cleaved-NOTCH1 (V1754) Polyclonal Antibody at dilution of 1:500.
E-AB-30054 Image
Immunohistochemistry of paraffin-embedded Rat brain using Cleaved-NOTCH1 (V1754) Polyclonal Antibody at dilution of 1:200
E-AB-30054 Image
Immunofluorescence analysis of Human lung cancer tissue using Cleaved-NOTCH1 (V1754) Polyclonal Antibody at dilution of 1:200.
| Manufacturer: | Elabscience |
| Shelf Life: | 12 months |
| Preservative: | 0.02% Sodium azide |
| Ph: | 7.4 |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | hN1;Neurogenic locus Notch homolog protein 1;NICD;NOTC1;Notch 1;Notch 1 intracellular domain;Notch homolog 1 translocation associated (Drosophila);notch1;TAN1;Translocation-associated notch protein TAN-1 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 120 ul, 20 ul, 60 ul, 200 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Synthesized peptide derived from the Internal region of human Notch 1 |
| Application: | IF, IHC-P, WB, IHC |
Description
Description: This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.
Additional Text
Gene Name
NOTCH1
Uniprot ID
P46531
Gene ID
4851
Purification
Affinity Purified
Antibody Clonality
Polyclonal
Concentration
1 mg/ml
Storage Note
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
E-AB-30054 Protocol
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