BCL-x Polyclonal Antibody
Catalogue Number: E-AB-30640-ELA
| Manufacturer: | Elabscience |
| Shelf Life: | 12 months |
| Preservative: | 0.02% Sodium azide |
| Ph: | 7.4 |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 120 ul, 20 ul, 60 ul, 200 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Synthesized peptide derived from human Bcl-x around the non-phosphorylation site of Thr47. |
| Application: | IF, IHC-P, WB, IHC |
Description
Description: Bcl x is a member of the Bcl 2 family of proteins, which function as regulators of apoptosis. It may provide neuroprotection against ischemic brian injury. Bcl x has two isoforms, Bcl xl (long) a 241 amino acid protein and Bcl xs (short) a 178 amino acid protein lacking a 63 amino acid domain that is well conserved among members of the Bcl2 family. Isoform Bcl-X(L) anti-apoptotic activity is inhibited by association with SIVA isoform 1. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, cytochrome c, from the mitochondrial membrane. The Bcl-X(S) isoform promotes apoptosis.
Additional Text
Gene Name
BCL2L1
Gene ID
598
Uniprot ID
Q07817
Purification
Affinity Purified
Antibody Clonality
Polyclonal
Concentration
1 mg/ml
Specificity
Apoptosis regulator Bcl X;Apoptosis regulator Bcl-X;Apoptosis regulator BclX;B cell lymphoma 2 like;B2CL1;Bcl 2 like 1 protein;Bcl X;Bcl xL;BCL XL/S;Bcl xS;Bcl-2-like protein 1;Bcl2 Like 1;Bcl2 related gene;Bcl2-L-1;BCL2L;Bcl2l1;BCLX;BclXL;BclXs;DKFZp781P2092;PPP1R52;Protein phosphatase 1 regulatory subunit 52
Storage Note
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
E-AB-30640 Protocol
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