BRCA1 Polyclonal Antibody
Catalogue Number: E-AB-30669-ELA
E-AB-30669 Image
E-AB-30669 Image
E-AB-30669 Image
E-AB-30669 Image
Western Blot analysis of 293T-UV, 22RV1 cells using BRCA1 Polyclonal Antibody at dilution of 1:1000.
E-AB-30669 Image
Immunohistochemistry of paraffin-embedded Human uterus cancer tissue using BRCA1 Polyclonal Antibody at dilution of 1:200.
E-AB-30669 Image
Immunofluorescence analysis of Rat lung tissue using BRCA1 Polyclonal Antibody at dilution of 1:200.
| Manufacturer: | Elabscience |
| Shelf Life: | 12 months |
| Preservative: | 0.02% Sodium azide |
| Ph: | 7.4 |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 120 ul, 20 ul, 60 ul, 200 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Synthesized peptide derived from human BRCA1 around the non-phosphorylation site of Ser1423. |
| Application: | IF, IHC-P, WB, IHC |
Description
Description: This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.
Additional Text
Gene ID
672
Gene Name
BRCA1
Uniprot ID
P38398
Purification
Affinity Purified
Antibody Clonality
Polyclonal
Specificity
BRCA 1;BRCA1;BRCA1 DNA repair associated;BRCA1/BRCA2 containing complex subunit 1;BRCA1/BRCA2-containing complex;subunit 1;BRCA1;BRCAI;BRCC 1;BRCC1;Breast and ovarian cancer susceptibility protein 1;Breast Cancer 1;Breast Cancer 1 Early Onset;Breast cancer type 1 susceptibility protein;BROVCA1;FANCS;IRIS;PNCA4;PPP1R53;Protein phosphatase 1 regulatory subunit 53;PSCP;RING finger protein 53;RNF53
Concentration
1 mg/ml
Storage Note
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
E-AB-30669 Protocol
SUPPORT
outstanding technical support
PRODUCT
we offer a full product guarantee
DELIVERY
we offer free delivery to UK universities and non profit organisations