AKT1 Polyclonal Antibody

Catalogue Number: E-AB-40032-ELA

Manufacturer:	Elabscience
Preservative:	0.02% Sodium azide
Ph:	7.3
Type:	Polyclonal Primary Antibody - Unconjugated
Alias:	AKT 1,AKT,AKT1,AKT1,MGC99656,PKB,PKB-ALPHA,PRKBA,Protein Kinase B Alpha,Protein kinase B,Proto-oncogene c-Akt,RAC Alpha,RAC,RAC-alpha serine/threonine-protein kinase,RAC-PK-alpha
Shipping Condition:	Blue Ice
Unit(s):	120 ul, 20 ul, 60 ul, 200 ul
Host name:	Rabbit
Clone:
Isotype:	IgG
Immunogen:	Recombinant Human RAC-alpha serine/threonine-protein kinase protein
Application:	IHC

Overview
Datasheets

Description

Description: The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.

Additional Text

Concentration

2 mg/ml

Uniprot ID

P31749

Purification

Affinity Purified

Accession Number

BC000479

Antibody Clonality

Polyclonal

Store at -20°C. Avoid freeze / thaw cycles.

E-AB-40032 Protocol

Price

£147.00

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