Catalogue Number: E-AB-40050-ELA
Manufacturer: | Elabscience |
Preservative: | 0.05% ProClin™ 300 |
Ph: | 7.3 |
Type: | Polyclonal Primary Antibody - Unconjugated |
Shipping Condition: | Blue Ice |
Unit(s): | 120 ul, 20 ul, 60 ul, 200 ul |
Host name: | Rabbit |
Clone: | |
Isotype: | IgG |
Immunogen: | Recombinant human Mothers against decapentaplegic homolog 3 protein |
Application: | WB, IHC |
Description: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
2 mg/ml
P84022
NP_005893
Affinity Purified
DKFZP586N0721,DKFZp686J10186,hMAD 3,hMAD-3,hSMAD3,HSPC193,HST17436,JV15 2,JV15-2,JV152,LDS1C,LDS3,MAD (mothers against decapentaplegic Drosophila) homolog 3,MAD homolog 3,Mad homolog JV15 2,Mad protein homolog,MAD,mothers against decapentaplegic homolog 3,Mad3,MADH 3,MADH3,MGC60396,Mothers against decapentaplegic homolog 3,Mothers against DPP homolog 3,SMA and MAD related protein 3,SMAD 3,SMAD,SMAD family member 3,SMAD,mothers against DPP homolog 3,Smad3,SMAD3
Polyclonal
Store at -20°C. Avoid freeze / thaw cycles.