STAT1 Polyclonal Antibody
Catalogue Number: E-AB-40052-ELA
E-AB-40052 Image
E-AB-40052 Image
E-AB-40052 Image
E-AB-40052 Image
Western Blot analysis of Hela and A549 cells using STAT1 Polyclonal Antibody at dilution of 1:600
E-AB-40052 Image
Immunohistochemistry of paraffin-embedded Rat liver using STAT1 Polyclonal Antibody at dilution of 1:50
E-AB-40052 Image
Immunohistochemistry analysis of paraffin-embedded Human Spleen using STAT1 Polyclonal Antibody(Elabscience® Product Detected by Lifespan).
| Manufacturer: | Elabscience |
| Preservative: | 0.05% ProClin™ 300 |
| Ph: | 7.3 |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 120 ul, 20 ul, 60 ul, 200 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Recombinant human Zinc finger protein SNAI1 protein |
| Application: | WB, IHC |
Description
Description: Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.
Additional Text
Concentration
2 mg/ml
Uniprot ID
P42224
Purification
Affinity Purified
Accession Number
BC002704
Specificity
Signal transducer and activator of transcription 1 91kD,CANDF7,DKFZp686B04100,IMD31A,IMD31B,IMD31C,ISGF 3,ISGF-3,OTTHUMP00000163552,OTTHUMP00000165046,OTTHUMP00000165047,OTTHUMP00000205845,Signal transducer and activator of transcription 1 91kDa,Signal transducer and activator of transcription 1,Signal transducer and activator of transcription 1,91kD,Signal transducer and activator of transcription 1-alpha/beta,STAT 1,Stat1,STAT1,STAT91,Transcription factor ISGF 3 components p91 p84,Transcription factor ISGF-3 components p91/p84
Antibody Clonality
Polyclonal
Store at -20°C. Avoid freeze / thaw cycles.
E-AB-40052 Protocol
SUPPORT
outstanding technical support
PRODUCT
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DELIVERY
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