IL10 Polyclonal Antibody

Catalogue Number: E-AB-40072-ELA

Manufacturer:Elabscience
Preservative:0.05% ProClin™ 300
Ph:7.3
Type:Polyclonal Primary Antibody - Unconjugated
Alias:CSIF,Cytokine synthesis inhibitory factor,GVHDS,IL 10,IL-10,IL10,IL10,IL10A,Interleukin 10,Interleukin-10,MGC126450,MGC126451,T-cell growth inhibitory factor,TGIF
Shipping Condition:Blue Ice
Unit(s): 120 ul, 20 ul, 60 ul, 200 ul
Host name: Rabbit
Clone:
Isotype: IgG
Immunogen: Recombinant Mouse Interleukin-10 protein
Application: IHC

Description

Description: Interleukin (IL)-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

Additional Text

Gene ID

3586

Concentration

2 mg/ml

Uniprot ID

P18893

Swiss Prot

P22301

Antibody Clonality

Polyclonal

Price
156.00


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