Catalogue Number: E-AB-40097-ELA
Manufacturer: | Elabscience |
Preservative: | 0.05% ProClin™ 300 |
Ph: | 7.3 |
Type: | Polyclonal Primary Antibody - Unconjugated |
Alias: | CDKI,CDKN1A-interacting zinc finger protein 1,Cip1-interacting zinc finger protein,CIZ1,CIZ1,cyclin dependent inhibitor 1A,LSFR1,Melanoma differentiation-associated protein,NP94,Nuclear protein NP94,OPHN3,P21,Zinc finger protein 356,ZNF356 |
Shipping Condition: | Blue Ice |
Unit(s): | 120 ul, 20 ul, 60 ul, 200 ul |
Host name: | Rabbit |
Clone: | |
Isotype: | IgG |
Immunogen: | Recombinant Human P21 protein |
Application: | WB |
Description: May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739).
1026
CDKN1A
2 mg/ml
P38936
Affinity Purified
Polyclonal
Store at -20°C. Avoid freeze / thaw cycles.