(KO Validated) BCL10 Polyclonal Antibody

Catalogue Number: E-AB-60188-ELA

Manufacturer:	Elabscience
Preservative:	0.02% Sodium azide
Type:	Polyclonal Primary Antibody - Unconjugated
Alias:	BCL10,CARMEN,CIPER,CLAP,IMD37,c-E10,mE10
Shipping Condition:	Blue Ice
Unit(s):	120 ul, 200 ul, 60 ul
Host name:	Rabbit
Clone:
Isotype:	IgG
Immunogen:	Recombinant fusion protein of human BCL10 (NP_003912.1).
Application:	WB

Overview
Datasheets

Description

Description: This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants.

Additional Text

Gene Name

BCL10

Concentration

0.5 mg/ml

Gene ID

8915

Uniprot ID

O95999

Purification

Affinity Purified

Antibody Clonality

Polyclonal

Storage Note

Store at -20°C. Avoid freeze / thaw cycles.

E-AB-60188 Protocol

Price

£360.00

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