(KO Validated) BCL10 Polyclonal Antibody

Catalogue Number: E-AB-60188-ELA

Manufacturer:Elabscience
Preservative:0.02% Sodium azide
Type:Polyclonal Primary Antibody - Unconjugated
Alias:BCL10,CARMEN,CIPER,CLAP,IMD37,c-E10,mE10
Shipping Condition:Blue Ice
Unit(s): 120 ul, 200 ul, 60 ul
Host name: Rabbit
Clone:
Isotype: IgG
Immunogen: Recombinant fusion protein of human BCL10 (NP_003912.1).
Application: WB

Description

Description: This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants.

Additional Text

Concentration

1 mg/ml

Gene ID

8915

Uniprot ID

O95999

Specificity

AI132454,B cell CLL/lymphoma 10,B cell lymphoma/leukemia10,B-cell CLL/lymphoma 10,B-cell leukemia/lymphoma 10,B-cell lymphoma/leukemia 10,Bcl 10,Bcl-10,Bcl10,BCL10,c E10,c-E10,C81403,CARD containing apoptotic signaling protein,CARD containing molecule enhancing NF kappa B,CARD containing molecule enhancing NF kB,CARD containing molecule enhancing NF-kB,CARD containing molecule enhancing NFkB,CARD containing proapoptotic protein,CARD like apoptotic protein,CARD-containing apoptotic signaling protein,CARD-containing molecule enhancing NF-kappa-B,CARD-containing proapoptotic protein,CARD-like apoptotic protein,CARMEN,Caspase recruiting domain containing protein,caspase-recruiting domain-containing protein,cCARMEN,cE 10,cE10,CED 3/ICH 1 prodomain homologous E10 like regulator,CED-3/ICH-1 prodomain homologous E10-like regulator,CED3/ICH1 prodomain homologous E10 like regulator,Cellular E10,Cellular homolog of vCARMEN,Cellular-E10,CIPER,CLAP,hCLAP,Mammalian CARD containing adapter molecule E10,Mammalian CARD-containing adapter molecule E10,mE 10,mE10,R-RCD1

Antibody Clonality

Polyclonal

Price
191.00


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