(KO Validated) ROCK1 Polyclonal Antibody
Catalogue Number: E-AB-62198-ELA
E-AB-62198 Image
E-AB-62198 Image
E-AB-62198 Image
E-AB-62198 Image
Western blot analysis of extracts from normal (control) and ROCK1 knockout (KO) HeLa cells using ROCK1 Polyclonal Antibody at dilution of 1:1000.
E-AB-62198 Image
Western blot analysis of extracts of various cell lines using ROCK1 Polyclonal Antibody at dilution of 1:1000.
E-AB-62198 Image
Immunohistochemistry of paraffin-embedded Mouse spleen using ROCK1 Polyclonal Antibody at dilution of 1:100 (40x lens).
| Manufacturer: | Elabscience |
| Preservative: | 0.02% Sodium azide |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | ROCK1,P160ROCK,ROCK-I |
| Shipping Condition: | Blue Ice |
| Unit(s): | 120 ul, 200 ul, 60 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Recombinant fusion protein of human ROCK1 (NP_005397.1). |
| Application: | WB, IHC |
Description
Description: This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18.
Additional Text
Concentration
1 mg/ml
Gene Name
ROCK1
Gene ID
6093
Uniprot ID
Q13464
Purification
Affinity Purified
Antibody Clonality
Polyclonal
Store at -20°C. Avoid freeze / thaw cycles.
E-AB-62198 Protocol
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