IkB alpha Polyclonal Antibody

Catalogue Number: E-AB-70089-ELA

Manufacturer:	Elabscience
Preservative:	0.02% Sodium azide
Type:	Polyclonal Primary Antibody - Unconjugated
Shipping Condition:	Blue Ice
Unit(s):	120 ul, 200 ul, 60 ul
Host name:	Rabbit
Clone:
Isotype:	IgG
Immunogen:	KLH conjugated Synthetic peptide corresponding to Mouse IKBα
Application:	IHC

Overview
Datasheets

Description

Description: Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor,alpha (NFKBIA,synonyms: IKBA,MAD-3,NFKBI). NFKB1 or NFKB2 is bound to REL,RELA ,or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB),which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA,or IKBKB) marks them for destruction via the ubiquitination pathway,thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime.

Additional Text

Concentration

1.3 mg/ml

Purification

Affinity Purified

Specificity

I kappa B alpha,I-kappa-B-alpha,IkappaBalpha,IkB-alpha,IKBA,IKBA,IKBalpha,MAD 3,MAD3,Major histocompatibility complex enhancer-binding protein MAD3,NF kappa B inhibitor alpha,NF-kappa-B inhibitor alpha,NFKBI,NFKBIA,Nuclear factor of kappa light chain gene enhancer in B cells,Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor alpha

UniProt ID

P25963, Q9Z1E3

Antibody Clonality

Polyclonal

Store at -20°C. Avoid freeze / thaw cycles.

E-AB-70089 Protocol

Price

£167.00

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