Recombinant cAMP Protein Kinase Catalytic Subunit Monoclonal Antibody
Catalogue Number: E-AB-81539-ELA
E-AB-81539 Image
E-AB-81539 Image
E-AB-81539 Image
E-AB-81539 Image
Western blot detection of cAMP Protein Kinase Catalytic subunit in K562,C6,3T3,Hela cell lysates using cAMP Protein Kinase Catalytic subunit Rabbit mAb(1:1000 diluted).Predicted band size:41kDa.Observed band size:41kDa.
E-AB-81539 Image
Immunohistochemistry of cAMP Protein Kinase Catalytic subunit in paraffin-embedded Human colon cancer tissue using cAMP Protein Kinase Catalytic subunit Rabbit mAb at dilution 1:100
E-AB-81539 Image
Immunofluorescence of cAMP Protein Kinase Catalytic subunit (green) in Hela cells using cAMP Protein Kinase Catalytic subunit Rabbit mAb at dilution 1:50, and DAPI(blue)
| Manufacturer: | Elabscience |
| Shelf Life: | 12 months |
| Preservative: | 0.01% Sodium azide |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul, 50 ul |
| Host name: | Rabbit |
| Clone: | R07-8H3 |
| Isotype: | IgG |
| Immunogen: | A synthetic peptide of human cAMP Protein Kinase Catalytic subunit |
| Application: | IF, IHC-P, IP, WB, IHC |
Description
Description: This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms.
Additional Text
Gene Name
PRKACA
Gene ID
5566
Uniprot ID
P17612
Concentration
300 ug/ml
Purification
Affinity Purified
Antibody Clonality
Monoclonal
Specificity
cAMP dependent protein kinase alpha catalytic subunit;cAMP dependent protein kinase beta catalytic subunit;cAMP dependent protein kinase catalytic beta subunit isoform 4ab;cAMP dependent protein kinase catalytic subunit alpha;cAMP dependent protein kinase catalytic subunit alpha;isoform 1;cAMP dependent protein kinase catalytic subunit beta;cAMP-dependent protein kinase catalytic subunit alpha;KAPCA;PKA C alpha;PKA C beta;PKA C-alpha;PKACA;PKACB;PPNAD4;PRKACA;PRKACAA;PRKACB;Protein kinase A catalytic subunit alpha;Protein kinase A catalytic subunit;Protein kinase A catalytic subunit beta;Protein kinase cAMP dependent catalytic alpha;Protein kinase cAMP dependent catalytic beta
Storage Note
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
E-AB-81539 Protocol
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