Recombinant Glucocorticoid Receptor Monoclonal Antibody

Catalogue Number: E-AB-81561-ELA

Manufacturer:	Elabscience
Shelf Life:	12 months
Preservative:	0.01% Sodium azide
Type:	Monoclonal Primary Antibody - Unconjugated
Alias:	GR;GCR;GRL;GCCR;GCRST
Shipping Condition:	Blue Ice
Unit(s):	100 ul, 50 ul
Host name:	Rabbit
Clone:	R04-8C8
Isotype:	IgG
Immunogen:	Recombinant protein of mouse Glucocorticoid Receptor
Application:	IF, WB

Overview
Datasheets

Description

Description: Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:10678832). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay . Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (PubMed:15037546).

Additional Text

Gene ID

2908

Gene Name

NR3C1

Concentration

300 ug/ml

Purification

Affinity Purified

UniProt ID

P06537

Antibody Clonality

Monoclonal

Storage Note

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

E-AB-81561 Protocol

E-AB-81561 MSDS

Price

£260.00

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