Pan Cadherin Polyclonal Antibody
Catalogue Number: E-AB-92116-ELA
E-AB-92116 Image
E-AB-92116 Image
E-AB-92116 Image
Western blot analysis of extracts of various cell lines using Pan Cadherin Polyclonal Antibody at 1:3000 dilution.
E-AB-92116 Image
Immunoprecipitation analysis of 900ug extracts of PC-3 cells using 3ug Pan Cadherin Polyclonal Antibody.Western blot was performed from the immunoprecipitate using Pan Cadherin Polyclonal Antibody at a dilution of 1:3000.
| Manufacturer: | Elabscience |
| Shelf Life: | 12 months |
| Preservative: | 0.01% Thimerosal |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 120 ul, 200 ul, 60 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | A synthetic peptide of human pan-cadherin |
| Application: | IP, WB |
Description
Description: Cadherin is one of a class of integral-membrane glycoproteins that are involved in cell to cell attachment for preserving the integrity of all solid tissues. Cadherins have three major regions: the Ca2+ -dependent extracellular region that mediates adhesion (cadherin to cadherin) for cell to cell binding; the transmembrane region; and the cytoplasmic region that extends into the cell and interacts with catenins, which in turn are linked to the actin of the cytoskeleton. Cadherins are differentially expressed during development and in adult organs. Since many cell types express multiple cadherin subclasses simultaneously (the combination differs with cell type), it can be inferred that the adhesion properities of individual cells are thus governed by varying the combinations of cadherins. Altered expression of cadherins are involved in invasion and metastasis of tumour cells. The classical cadherins (e.g. E-, N-, and P-cadherins) are the most common family members. E-cadherin (also known as uvomorulin) is concentrated in the belt desmosome in epithelial cells; N-cadherin is found in nerve, muscle, and lens cells and helps maintain the integrity of neuronal aggregates; P-cadherin is expressed in placental and epidermal cells.
Additional Text
Purification
Affinity Purified
Gene ID
1000; 1001; 1002; 999
Uniprot ID
P12830, P19022, P22223, P55283
Gene Name
CDH1, CDH2, CDH3, CDH4
Antibody Clonality
Polyclonal
Concentration
1 mg/ml
Storage Note
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
E-AB-92116 Protocol
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