Elab Fluor® 647 Anti-Mouse CD162 Antibody[4RA10]
Catalogue Number: E-AB-F1034UM-ELA
E-AB-F1034UM Image
E-AB-F1034UM Image
E-AB-F1034UM Image
C57BL/6 murine splenocytes are stained with Elab Fluor® 647 Anti-Mouse CD162 Antibody and FITC Anti-Mouse CD3 Antibody (Left). Splenocytes stained with FITC Anti-Mouse CD3 Antibody and Elab Fluor® 647 Rat IgG1, κ Isotype Control (Right) are used as control.
E-AB-F1034UM Image
| Manufacturer: | Elabscience |
| Shelf Life: | 12 months |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Alias: | CD162;P-selectin glycoprotein ligand 1;PSGL-1;Selectin P ligand;Selplg |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug, 25 ug |
| Host name: | Rat |
| Clone: | 4RA10 |
| Isotype: | IgG1, kappa |
| Immunogen: | |
| Application: | FC |
Description
Description: The 4RA10 antibody reacts with the N-terminal functional peptide of CD162 (P-selectin glycoprotein ligand-1, PSGL-1), encoded by the Selpl gene. PSGL-1 is expressed on the cell surface as a homodimer of approximately 230 kDa. In the mouse, Selpl mRNA is detected in most tissues, with high levels found in hematopoietic cells, brain, and adipose tissue. Flow cytometric analyses have revealed CD162 expression on bone marrow-derived mast and dendritic cells, splenic leukocytes, platelets, peripheral blood neutrophils, and neutrophil and T-cell lines. PSGL-1 is a ligand for P-selectin (CD62P) and is involved in leukocyte rolling, the migration of leukocytes into inflamed tissues, and responses to vascular injury. It is a sialomucin that must be specifically sialylated, fucosylated, and sulfated to bind P-selectin. There is also evidence that other ligands for PSGL-1 and CD62P may exist. 4RA10 mAb is reported to block the binding of mouse leukocytes to CD62P and CD62L.
Additional Text
Gene Name
SELPLG
Concentration
0.5 mg/ml
Uniprot ID
Q62170
Gene ID
20345
Antibody Clonality
Monoclonal
Storage Note
This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
E-AB-F1034UM MSDS
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