Purified Anti-Mouse CD103 Antibody[M290]
Catalogue Number: E-AB-F1090A-ELA
| Manufacturer: | Elabscience |
| Preservative: | 0.05% ProClin™ 300 |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | Integrin alpha-E;Itgae;Integrin alpha M290;CD103 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug, 25 ug, 1 mg, 100 mg, 25 mg, 5 mg, 50 mg |
| Host name: | Rat |
| Clone: | M290 |
| Isotype: | IgG2a, kappa |
| Immunogen: | |
| Application: | FC, Blk |
Description
Description: CD103 is a type I transmembrane glycoprotein known as αE integrin or Integrin αIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.
Additional Text
Gene Name
ITGAE
Gene ID
16407
Uniprot ID
Q60677
Antibody Clonality
Monoclonal
Concentration
>=1 mg/ml
Storage Note
Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.
E-AB-F1090A MSDS
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