APC Anti-Human CD8a Antibody[OKT-8]
Catalogue Number: E-AB-F1110E-ELA
| Manufacturer: | Elabscience |
| Preservative: | 0.05% ProClin™ 300 |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Alias: | T-cell surface glycoprotein CD8 alpha chain,CD8A,T-lymphocyte differentiation antigen T8/Leu-2,MAL |
| Shipping Condition: | Blue Ice |
| Unit(s): | 20 Tests, 100 Tests, 200 tests |
| Host name: | Mouse |
| Clone: | OKT-8 |
| Isotype: | IgG2a, kappa |
| Immunogen: | |
| Application: | FC |
Description
Description: CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.
Additional Text
Gene ID
925
Gene Name
CD8A
Uniprot ID
P01732
Antibody Clonality
Monoclonal
Storage Note
Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
E-AB-F1110E Protocol
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