AF/LE Purified Anti-Mouse CD274/PD-L1 Antibody[10F.9G2]
Catalogue Number: E-AB-F11320-ELA
| Manufacturer: | Elabscience |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | B7-H1; PD-L1;Programmed cell death ligand 1;B7 homolog 1;B7-H; B7H1; PDL1; PDCD1L1; PDCD1LG1 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg, 100 mg, 100 ug, 25 mg, 25 ug, 5 mg, 50 mg |
| Host name: | Rat |
| Clone: | 10F.9G2 |
| Isotype: | IgG2b, kappa |
| Immunogen: | |
| Application: | FC, Blk |
Description
Description: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.
Additional Text
Gene Name
CD274
Uniprot ID
Q9EP73
Gene ID
60533
Antibody Clonality
Monoclonal
Concentration
>=1 mg/ml
Storage Note
Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
E-AB-F11320 MSDS
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