Biotin Anti-Human CD274/PD-L1 Antibody[29E.2A3]
Catalogue Number: E-AB-F1133B-ELA
| Manufacturer: | Elabscience |
| Shelf Life: | 12 months |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Alias: | B7H1PD-L1PDCD1L1PDCD1LG1PDL1;B7 homolog 1;B7-H;B7-H1;Programmed cell death ligand 1 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 25 ug, 100 ug |
| Host name: | Mouse |
| Clone: | 29E.2A3 |
| Isotype: | IgG2b, kappa |
| Immunogen: | |
| Application: | FC |
Description
Description: CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.
Additional Text
Gene Name
CD274
Gene ID
29126
Concentration
0.5 mg/ml
Uniprot ID
Q9NZQ7
Antibody Clonality
Monoclonal
Storage Note
This product can be stored at 2-8°C for 12 months. Do not freeze.
E-AB-F1133B MSDS
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