PE/Elab Fluor® 594 Anti-Human CD49d Antibody[9F10]
Catalogue Number: E-AB-F1144P-ELA
| Manufacturer: | Elabscience |
| Shelf Life: | 12 months |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Alias: | CD49 antigen-like family member D;CD49d;ITGA4;Integrin alpha-4;Integrin alpha-IV;VLA-4 subunit alpha |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 tests, 20 tests, 200 tests |
| Host name: | Mouse |
| Clone: | 9F10 |
| Isotype: | IgG1, kappa |
| Immunogen: | |
| Application: | FC |
Description
Description: CD49d is a 150 kD α integrin chain known as α4 integrin or VLA-4 α chain. It forms a heterodimer with either integrin β1 (α4β1, VLA-4) or β7 (α4β7). CD49d is expressed broadly on T lymphocytes, B lymphocytes, monocytes, thymocytes, eosinophils, basophils, mast cells, NK cells, dendritic cells, and some non-hematopoietic cells, but not on normal red blood cells, platelets or neutrophils. VLA-4 binds to VCAM-1 (CD106) and fibronectin. α4β7 is the receptor for VCAM-1 and MAdCAM-1. CD49d participates in mononuclear cell trafficking to endothelial sites of inflammation and has roles in cell-cell interactions and cell adhesion to extracellular matrices. CD49d is involved in lymphocyte migration, T cell activation, and hematopoietic stem cell differentiation. CD49d is a marker to isolate pure populations of Treg cells due to its absence on Foxp3+ cells.
Additional Text
Gene Name
ITGA4
Gene ID
3676
Uniprot ID
P13612
Concentration
5 ul/test
Antibody Clonality
Monoclonal
Storage Note
This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
E-AB-F1144P MSDS
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