APC Anti-Human CD127/IL-7RA Antibody[A019D5]
Catalogue Number: E-AB-F1152E-ELA
| Manufacturer: | Elabscience |
| Preservative: | 0.05% ProClin™ 300 |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Alias: | Interleukin-7 receptor subunit alpha,IL-7RA,CDw127,CD127,IL-7Rα |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 tests, 20 tests, 200 tests |
| Host name: | Mouse |
| Clone: | A019D5 |
| Isotype: | IgG1, kappa |
| Immunogen: | |
| Application: | FC |
Description
Description: CD127 is a 60-90 kD type I transmembrane glycoprotein also known as IL-7 receptor α chain or IL-7Rα. It forms a heterodimer with the common γ chain (γc or CD132) which is shared with the receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21. CD127 is expressed on immature B cells through early pre-B stage cells, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be a useful marker for identifying memory and effector T cells. Studies have shown that CD127 expression is down-modulated on Treg cells. It can be used as a marker for differentiation of Treg and conventional T cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cell proliferation and development.
Additional Text
Gene ID
3575
Uniprot ID
P16871
Gene Name
IL7R
Antibody Clonality
Monoclonal
Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
E-AB-F1152E Protocol
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