APC Anti-Human CD127/IL-7RA Antibody[A019D5]

Catalogue Number: E-AB-F1152E-ELA

Preservative:0.05% ProClin™ 300
Type:Monoclonal Primary Antibody - Conjugated
Alias:Interleukin-7 receptor subunit alpha,IL-7RA,CDw127,CD127,IL-7Rα
Shipping Condition:Blue Ice
Unit(s): 100 tests, 20 tests, 200 tests, 50 tests
Host name: Mouse
Clone: A019D5
Isotype: IgG1, kappa
Application: FC


Description: CD127 is a 60-90 kD type I transmembrane glycoprotein also known as IL-7 receptor α chain or IL-7Rα. It forms a heterodimer with the common γ chain (γc or CD132) which is shared with the receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21. CD127 is expressed on immature B cells through early pre-B stage cells, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be a useful marker for identifying memory and effector T cells. Studies have shown that CD127 expression is down-modulated on Treg cells. It can be used as a marker for differentiation of Treg and conventional T cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cell proliferation and development.

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