Elab Fluor®700 Anti-Human CD196/CCR6 Antibody[G034E3]

Catalogue Number: E-AB-F1158M1-ELA

Manufacturer:	Elabscience
Shelf Life:	12 months
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	CMKBR6; GPR29; STRL22;CKRL3;GPRCY4
Shipping Condition:	Blue Ice
Unit(s):	100 tests, 2 x 100 tests, 20 tests
Host name:	Mouse
Clone:	G034E3
Isotype:	IgG2b, kappa
Immunogen:
Application:	FC

Overview
Datasheets

Description

Description: CCR6, also known as CD196/CCR6, is a chemokine receptor that is expressed on immature dendritic cells, B lymphocytes, and memory T cells. CCR6 binds CCL20, although members of the β defensin family also bind CCR6 with a lower affinity. CCR6 positive cells, and its ligand CCL20, have been detected in numerous organs, especially the secondary lymphoid organ. CCL20 is selectively made by the follicle-associated epithelium (FAE) overlying Peyers Patches (PPs) and isolated lymphoid follicles (ILFs). CCL20 contributes to the recruitment of CCR6-expressing B cells to these structures. In humans, CCR6 can function to mediate arrest of T cells on dermal endothelial cells and is highly expressed on T cells resident in both normal and psoriatic skin. CCR6 and/or CCL20 have been implicated in the pathogenesis of rheumatoid arthritis and inflammatory bowel disease. Human T cells that are able to produce IL-17 express CCR6. It suggests that CCL20 and CCR6 have a role in inflammatory diseases by recruiting Th17 cells to target tissues.

Additional Text

Gene Name

CCR6

Uniprot ID

P51684

Gene ID

1235

Antibody Clonality

Monoclonal

Storage Note

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

E-AB-F1158M1 MSDS

E-AB-F1158M1 Datasheet

Price

£238.00

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