Elab Fluor® Violet 450 Anti-Human CD196/CCR6 Antibody[G034E3]

Catalogue Number: E-AB-F1158Q-ELA

Manufacturer:	Elabscience
Shelf Life:	12 months
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	CMKBR6GPR29STRL22;CKRL3;GPRCY4
Shipping Condition:	Blue Ice
Unit(s):	100 tests, 2 x 100 tests, 20 tests
Host name:	Mouse
Clone:	G034E3
Isotype:	IgG2b, kappa
Immunogen:
Application:	FC

Overview
Datasheets

Description

Description: CCR6, also known as CD196/CCR6, is a chemokine receptor that is expressed on immature dendritic cells, B lymphocytes, and memory T cells. CCR6 binds CCL20, although members of the β defensin family also bind CCR6 with a lower affinity. CCR6 positive cells, and its ligand CCL20, have been detected in numerous organs, especially the secondary lymphoid organ. CCL20 is selectively made by the follicle-associated epithelium (FAE) overlying Peyers Patches (PPs) and isolated lymphoid follicles (ILFs). CCL20 contributes to the recruitment of CCR6-expressing B cells to these structures. In humans, CCR6 can function to mediate arrest of T cells on dermal endothelial cells and is highly expressed on T cells resident in both normal and psoriatic skin. CCR6 and/or CCL20 have been implicated in the pathogenesis of rheumatoid arthritis and inflammatory bowel disease. Human T cells that are able to produce IL-17 express CCR6. It suggests that CCL20 and CCR6 have a role in inflammatory diseases by recruiting Th17 cells to target tissues.

Additional Text

Gene Name

CCR6

Uniprot ID

P51684

Gene ID

1235

Concentration

5 ul/test

Antibody Clonality

Monoclonal

Storage Note

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

E-AB-F1158Q MSDS

E-AB-F1158Q Datasheet

Price

£238.00

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