Elab Fluor®700 Anti-Human CD197/CCR7 Antibody[G043H7]

Catalogue Number: E-AB-F1159M1-ELA

Manufacturer:	Elabscience
Shelf Life:	12 months
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	EBI1; EVI1;CCR-7;CDw197;CMKBR7
Shipping Condition:	Blue Ice
Unit(s):	100 tests, 2 x 100 tests, 20 tests
Host name:	Mouse
Clone:	G043H7
Isotype:	IgG2a, kappa
Immunogen:
Application:	FC

Overview
Datasheets

Description

Description: CCR7, also known as CD197, is a chemokine receptor that binds CCL19 and CCL21. CCR7 and its ligands link innate and adaptive immunity by affecting interactions between T cells and dendritic cells and their downstream effect. Naive T cells enter the lymph node through high endothelial venules, which express CCL21. Dendritic cells and macrophages enter the lymph node through afferent lymphatics. The encounter of T cells and dendritic cells in the T cell zone is CCR7-dependent. In addition, during immunological surveillance, B cells recirculate between B-cell-rich compartments (follicles or B cell zones) in secondary lymphoid organs, surveying for antigen. After antigen binding, B cells move to the boundary of B and T zones to interact with T-helper cells; this B cell migration is directed by CCR7 and its ligands. CCR7-positive cancer cell expression has been associated with lymph node metastasis.

Additional Text

Gene ID

1236

Gene Name

CCR7

Uniprot ID

P32248

Antibody Clonality

Monoclonal

Storage Note

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

E-AB-F1159M1 MSDS

E-AB-F1159M1 Datasheet

Price

£238.00

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