PerCP/Cyanine5.5 Anti-Human CD194/CCR4 Antibody[L291H4]
Catalogue Number: E-AB-F1366J-ELA
E-AB-F1366J Image
E-AB-F1366J Image
E-AB-F1366J Image
Human peripheral blood lymphocytes are stained with FITC Anti-Human CD3 Antibody and PerCP/Cyanine5.5 Anti-Human CD194/CCR4 Antibody[L291H4] (Left). Lymphocytes are stained with FITC Anti-Human CD3 Antibody and PerCP/Cyanine5.5 Mouse IgG1, κ Isotype Control (Right).
E-AB-F1366J Image
| Manufacturer: | Elabscience |
| Shelf Life: | 12 months |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Alias: | CC-CKR-4;CKR4;CMKBR4;ChemR13;HGCN:14099;K5-5;MGC88293 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 tests, 2 x 100 tests, 20 tests |
| Host name: | Mouse |
| Clone: | L291H4 |
| Isotype: | IgG1, kappa |
| Immunogen: | |
| Application: | FC |
Description
Description: CD194, also known as CCR4, is a CC chemokine receptor. It binds CCL17 and CCL22 and is expressed on a subset of T and B cells, basophils, monocytes, and NK cells. Human Th2 cells are characterized by the expression of CCR4 and CCR8, and these receptors are regulated differently during Th2 development. Human peripheral blood Tregs can be divided into two distinct populations based on the expression of CCR4. Freshly isolated Tregs express CCR4 and presumably represent memory-type Tregs, and CCR4- Tregs require CD3-mediated activation to acquire a regulatory activity. Depletion of CCR4+ T cells leads to Th1-type polarization of CD4+ T cells and augmentation of CD8+ T cell responses to tumor antigens. CCR4 and its ligands are important for the recruitment of memory T cells into the skin in various cutaneous immune diseases.
Additional Text
Gene Name
CCR4
Uniprot ID
P51679
Gene ID
1233
Concentration
5 ul/test
Antibody Clonality
Monoclonal
Storage Note
This product can be stored at 2-8°C for 12 months. Do not freeze.
E-AB-F1366J MSDS
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