SARS-CoV-2 NSP3 Polyclonal Antibody(2019-nCoV)
Catalogue Number: E-AB-V1039-ELA
| Manufacturer: | Elabscience |
| Shelf Life: | 12 months |
| Preservative: | 0.05% ProClin™ 300 |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | Non-structural protein 3;PL2-PRO;Papain-like proteinase;PL-PRO;Replicase polyprotein 1a |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul, 50 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Recombinant SARS-CoV-2 NSP3 |
| Application: | ELISA |
Description
Description: Responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Participates together with nsp4 in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF3. Prevents also host NF-kappa-B signaling.
Additional Text
Concentration
0.33 mg/ml
Antibody Clonality
Polyclonal
Storage Note
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
E-AB-V1039 Protocol
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