Caspase-2, human recombinant proteinase
Catalogue Number: E1002-APE
| Manufacturer: | Apexbio |
| Type: | Proteases |
| Shipping Condition: | Blue Ice |
| Storage Condition: | -70°C |
Description
Description: Caspase-2 (also know as Ich-1, Nedd-2) is a member of the caspase-family of cysteine proteases. Caspase-2 exists in cells as an inactive proenzyme. During apoptosis, pro-caspase-2 is processed at aspartate residues by self-proteolysis and/or cleavage by upstream caspases. The active caspase-2 is a heterotetramer consisting of two large (19 kDa) and two small (12 kDa) subunits.The recombinant active human caspase-2 is expressed in E. coli. The active caspase-2 preferentially cleaves caspase-2 substrates (VDVAD-AFC or VDVAD-pNA) and is routinely tested for its ability to enzymatically cleave Ac-VDVAD-pNA or Ac-VDVAD-AFC.Active caspase-2 is useful in studying enzyme regulation, determining target substrates, screening caspase inhibitors, or as a positive control in caspase activity assays. Recommend using 1 unit/assay for analyzing caspase activity.
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