Endoglin (CD105, END, Endoglin, FLJ41744, HHT1, ORW, ORW1) (MaxLight 550)

Catalogue Number: E2287-03A-ML550-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™550.
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	9H229 (P3D1)
Isotype:	IgG2a
Immunogen:	Human resting umbilical vein endothelial cells. Cellular Localization: Membrane; Single-pass type I membrane protein. Species Sequence Homology: rat
Application:	FC, ICC, IP, WB, IHC, FLISA

Overview
Datasheets

Description

Description: MaxLight™550 is a new Yellow-Green photostable dye conjugate comparable to Alexa Fluor™546, 555, DyLight™549 , Cy3™, TRITC and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (550nm); Emission (575nm); Extinction Coefficient 150,000. Endoglin is a homodimeric integral membrane glycoprotein comprised of 95kD subunit. Endoglin is a component of the TGF-B receptor system that functions as an ancillary receptor influencing binding of the Transforming Growth Factor beta (TGF-B) family ligands to signaling receptors. Endoglin binds TGF-B1 and TGF-B3 with high affinity but does not bind TGF-B2. Endoglin is expressed by vascular endothelial cells and syncytiotrophoblasts of placenta and is weakly expressed by stromalfibroblasts. It is also expressed by U937 cells and activated macrophages. Endoglin expression is up regulated on activated endothelium in tissues undergoing angiogenesis, such as in tumors, or in cases of wound healing or dermal inflammation.

Additional Text

Gene Name

ENG

Gene ID

2022

Uniprot ID

P17813

Specificity

Recognizes human endoglin. Species Crossreactivity: mouse. Species Sequence Homology: rat

Accession Number

NM_000118.1

Purification

Purified

Antibody Clonality

Monoclonal

E2287-03A-ML550 Datasheet

Price

£979.00

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