Epidermal Growth Factor Receptor (erbB, EGFR) (Biotin)
Catalogue Number: E3375-01P-BIOTIN-USB
| Manufacturer: | United States Biological |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | EGFR1 |
| Isotype: | IgG2b, kappa |
| Immunogen: | Human epidermoid carcinoma line A431. Epitope: Between amino acid residues 6-273 of human EGFR. Cellular Localization: Cell Membrane and Secreted. |
| Application: | FC, ICC, IF, WB, IHC |
Description
Description: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. The protein kinase family is one of the largest families of proteins in eukaryotes, classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. Epidermal Growth factor receptor (EGFR) is the prototype member of the type 1 receptor tyrosine kinases. EGFR overexpression in tumors indicates poor prognosis and is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.
Additional Text
Purification
Protein A purified
Antibody Clonality
Monoclonal
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