Factor Va, light chain, fragment E, 74kD (HRP)

Catalogue Number: F0011-24A-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.2. Labeled with Horseradish Peroxidase (HRP) .
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	50 ug
Host name:	Mouse
Clone:	3H368
Isotype:	IgG1
Immunogen:	Purified human Factor V
Application:	ELISA, WB, RIA

Overview
Datasheets

Description

Description: Factor V is a large, single chain, plasma glycoprotein which is an essential component in the blood coagulation cascade (1). During coagulation, the procofactor, factor V, is converted to the active cofactor, factor Va, via limited proteolysis by the serine protease a-thrombin (illustrated above), and less efficiently by factor Xa. The active cofactor is composed of an NH2-terminal derived heavy chain (Mr=94,000) and a COOH-terminal derived light chain (Mr=74,000) which remain non-covalently associated in the presence of calcium ions. Factor Va serves as a cofactor for the serine protease factor Xa. Factor Va and Xa assemble on a phospholipid surface in a non-covalent and calcium ion-dependent manner, to form the prothrombinase complex. The prothrombinase complex is responsible for the rapid conversion of the zymogen prothrombin to the active serine protease, a-thrombin. Assembly of the prothrombinase complex increases the rate at which prothrombin is converted to thrombin by nearly 300,000-fold relative to the rate with factor Xa alone. Down regulation of the prothrombinase complex is accomplished partly through the inactivation of factor Va by activated protein C.

Additional Text

Caution

FOR RESEARCH USE ONLY

Specificity

Recognizes human Factor Va, light chain, (fragment E, 74,000). Does not react with intact Factor V.

Purification

Purified

Antibody Clonality

Monoclonal

F0011-24A Datasheet

Price

£677.00

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Quantity
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