Fas (CD95, APO-1) (MaxLight 490)

Catalogue Number: F0019-62-ML490-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™490.
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	AI196731\|APO1\|apo-1 antigen\|apoptosis-mediating surface antigen FAS\|APT1\|CD95\|Fas (TNF receptor superfamily member)\|Fas antigen\|FASLG receptor\|lpr\|lymphoproliferation\|TNFR6\|Tnfrsf6\|tumor necrosis factor receptor superfamily member 6
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Rat
Clone:	0.T.44 (7C10)
Isotype:	IgG2a
Immunogen:	Recombinant protein containing the cytoplasmic domain of mouse Fas
Application:	IP, WB

Overview
Datasheets

Description

Description: MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. Apoptosis or programmed-cell death is a physiological process essential for the normal development and maintenance of homeostasis in many organisms. This "cellular suicide" can be mediated by the Fas antigen (CD95, APO1), a cell-surface glycoprotein, 40-50kD, that belongs to the nerve growth factor/tumor necrosis factor (TNF) receptor family. Mice carrying the lymphoproliferation (lpr) mutation, which develop lymphoadenopathy and suffer from a systematic lupus erythematosus-like autoimmune disease, have defects in the Fas gene. Fas is expressed in several tissues including blood, where it expression is upregulated on activated T and B lymphocytes and natural killer cells. Binding of the Fas antigen by agonistic anti-Fas antibody has been shown to induce apoptosis.

Additional Text

Gene Name

FAS

Uniprot ID

P25446

Gene ID

14102

Specificity

Recognizes mouse Fas, Mr 45kD. Species Crossreactivity: bovine

Purification

Protein G purified

Antibody Clonality

Monoclonal

F0019-62-ML490 Datasheet

Price

£1,070.00

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Quantity
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